We previously demonstrated that cholesterol deprivation increases endothelial cyclooxygenase-2 (COX-2)-dependent prostacyclin [prostaglandin I2 (PGI2)] production in vitro.Cholesterol directly regulates gene transcription through the sterol response element binding protein (SREBP).In this work, we demonstrate that SREBP directly regulates COX-2 exp
Introduction.The incidence of priapism in adults is higher than in children.Although approximately 50% of all episodes of priapism are thought to be idiopathic, there are a number of known specific causes of this disorder.In adults intracavernous therapy with papaverine, phentolamine, alprostadil or combinations of these agents is the most common D
An age-related distribution of Cryptosporidium species has been reported in cattle, with C.parvum being predominant in suckling calves, C.bovis and C.ryanae being predominant in post-weaned calves and C.andersoni being predominant in adults.However, variants to this pattern have recently been reported.Thus, fecal samples (n = 594) from asymptomatic
Abstract Background Drug resistance continues Kids to be a major limiting factor across diverse anti-cancer therapies.Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer.For op